OPLL颈椎后纵韧带骨化 .ppt

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1、Ossification of the posterior longitudinal ligament(OPLL)results from pathologic replacement of the PLL with lamellar bone,potentially causing spinal cord compression and neurologic deteriorationOPLL was first described in Japanese patients and has classically been considered a cause of myelopathy i

2、n patients of East Asian originspondylosismyelopathyradiculopathystenosisdisc herniationAmong patients in Japan with cervical spine disorders,the incidence has been estimated at 1.9%to 4.3%and,in other Asian countries,up to 3.0%OPLL has been recognized as an etiology of myelopathy regardless of ethn

3、icity,with an estimated incidence rate of 0.1%to 1.7%among North Americans and Europeans PathoanatomyThe PLL runs along the dorsal surface of the C1 anterior arch and cervical vertebral bodies and consists of longitudinal fibers confluent with the tectorial membrane cranially and ending at the sacru

4、m caudallyfunctionally,the PLL resists spine hyperflexionPathophysiologyThe pathologic process leading to OPLL begins with chondroblast-and fibroblast-like spindle cell proliferation,along with vascular infiltration leading to PLL degeneration and hypertrophy.Endochondral ossification follows,result

5、ing in its replacement with mature lamellar boneGenetics,local tissue characteristics,and associated medical comorbidities have all been implicated in this final common pathwayMedical comorbidities are also associated with the development of OPLLUp to 50%of Caucasian patients with OPLL also have dif

6、fuse idiopathic skeletal hyperostosisHypoparathyroidism,hypophosphatemic rickets,hyperinsulinemia,and obesity have been identified as risk factorsNatural HistoryPatients with OPLL commonly present in their fifth and sixth decades,with men affected twice as often as women.Most patients have some neur

7、ologic symptoms at diagnosis,with 28%to 39%fulfilling diagnostic criteria for myelopathyIn patients with myelopathy,64%had deteriorated,however,and 89%of patients with Nurick grade 3 or 4 myelopathy who refused surgery had progressed to a wheelchair-or bed-bound stateRisk factors for the development

8、 of myelopathy include 60%spinal canal stenosis,6 mm of space available for the cord,increased cervical range of motion,and OPLL that is laterally deviated within the spinal canalAge,gender,and the number of levels affected by OPLL do not affect the prognosisClinical PresentationChanges in gait or b

9、alance,loss of fine motor control,and upper extremity weakness,numbness,or paresthesias are suggestive of myelopathyEarly muscular fatigue or worsening symptoms at the extremes of cervical motion are also concerningPatients with OPLL are at an increased risk of acute spinal cord injury with trauma,a

10、nd rapid neurologic deterioration in association association with even a minor trauma or whiplash injury should raise concern for the development of central cord syndromePhysical ExaminationRadiologic EvaluationThe lateral radiograph is also used to determine the relationship of the OPLL to the kyph

11、osis line(K-line),which is drawn from the center of the canal at C2 to the center of the canal at C7A large OPLL mass or loss of cervical lordosis causes the OPLL to protrude posterior to the K-line(referred to as K-line negative).This is a negative prognostic factor for posterior surgery aloneCT wi

12、th sagittal and coronal reformatting has emerged as the benchmark for radiographic evaluation of OPLL and is necessary to reliably characterize it Greater than 60%canal occupancy at any level and a laterally deviated mass are associated with high rates of myelopathyThis“double layer sign”on axial or

13、 sagittal CT images is associated with dural tear rates 50%with anterior decompression versus 13%when the sign is absentNonsurgical ManagementProphylactic surgery is neither necessary nor recommended Management includes temporary immobilization with a neck brace,steroidal or nonsteroidal anti-inflam

14、matory medications,activity modification,and physical therapypatients should be advised to avoid activities that may result in sudden or excessive cervical spine motion because OPLL is associated with a high rate of acute spinal cord injury,even in patients who do not meet surgical criteriaSurgical

15、TreatmentSurgical decompression is the treatment of choice for patients with Nurick grade 3 or 4 myelopathy or severe radiculopathy caused by OPLL via either an anterior or posterior approachAnterior Decompression and FusionProponents argue that it allows for a superior decompression and is more eff

16、ective at maintaining or restoring cervical lordosis than is posterior surgery.Associated anterior pathology,such as disk herniations,can also be addressedDisadvantages include technical difficulty,inability to decompress cranial to C2,and high rates of pseudarthrosis and dysphagia when three or mor

17、e levels require treatment Dural tears are also much more common with an anterior approach,given that anterior dural ossification occurs in 13%to 15%Exposure is provided by the standard Smith-Robinson approach,and diskectomy,hemicorpectomy,or subtotal corpectomy sufficient to allow exposure of the u

18、nderlying OPLL mass is performedCorpectomies of up to five levels have been performed with success,but removal of three or more contiguous levels is associated with increased complication and reoperation ratesComplications occur as part of the approach(eg,dysphagia,dysphonia),the decompression(eg,C5

19、 palsy,dural tears),or the fusion(eg,graft subsidence,pseudarthrosis)Nerve root palsies occur in 4%to 17%of patients through either direct trauma or traction.Patients present with weakness,numbness,pain,or paresthesias,most commonly in the C5 distributionDural tears occur in 4%to 20%of patients,ofte

20、n because of dural ossification or attenuation.Cerebrospinal fluid leakage may result in pseudomeningocele or fistula formation,leading to neural damage,airway compression,meningitis,or wound complicationsTears recognized intraoperatively are treated by direct repair or by application of autogenous

21、fascial or synthetic collagen grafts.Closure of pinhole defects or augmentation of repairs is done with thrombogenic sealants,such as fibrin glue or gelatin foam.Postoperatively,diverting lumbar drains and bed rest can be usedIn an effort to reduce dural tear rates,Yamaura et al introduced the“anter

22、ior floating method”for cervical decompression,consisting of subtotal vertebral body resection and thinning,but not removal,of the OPLL.The posterior vertebral body is not reconstructed,allowing the OPLL to“float”anteriorly and away from the spinal canal.At 5-year follow-up,the authors achieved a me

23、an recovery rate of 68.5%and improvement in Japanese Orthopaedic Association scores from 8.3 to 14.2.No leaks of cerebrospinal fluid occurred,but 14%of patients were left with an inadequate decompression.In these patients,or with OPLL progression,the authors recommended subsequent posterior decompre

24、ssion.When addressing more than two or three levels,fibular strut grafts are preferred for their structural support.For one or two levels,structural grafts of tricortical iliac crest,fibula,and vertebral bodies have all been described.More recently,interbody cages with nonstructural bone graft or bo

25、ne graft substitutes have been used.Overall rates of pseudarthrosis vary from 3%to 15%,with the highest rates occurring in patients undergoing fusion of three or more levels.Posterior DecompressionWhen more than two or three cervical levels are affected by OPLL,posterior surgery(ie,laminoplasty,or l

26、aminectomy and fusion)is preferred because of the technical ease and lower rate of complications.Disadvantages include the risk of postoperative disease progression,inability to correct cervical kyphosis,and poor results in K-line negative patients.Laminoplasty accomplishes this by hinging open the

27、laminae with either an“open door”or“French door”technique,resulting in a 30%to 40%increase in the size of the spinal canalLaminectomy and fusion entails removal of the laminae followed by instrumented posterolateral fusion,resulting in a 70%to 80%increase in canal volumeA full analysis of the advant

28、ages and disadvantages between laminoplasty compared with laminectomy and fusion has been discussed elsewhereOur preference is to use laminectomy and fusion for OPLL because the retained cervical motion with laminoplasty may allow disease progression,and the risk for progression to kyphosis at the a

29、ffected levels is eliminated with fusionFor severe disease,recovery rates after posterior decompression appear to be lower than those following anterior decompression,but with a lower complication rateIwasaki et al retrospectively compared the results of anterior decompression and fusion with those

30、of laminoplasty;they reported better outcomes after anterior surgery in patients with an OPLL mass occupying 60%of the canal;however,it results in a reoperation rate of 26%versus 2%in the laminoplasty group.With60%canal occupancy,recovery rates were equivalent.A prospective comparison of anterior de

31、compression and fusion versus laminoplasty found similar results.Patients with 50%canal occupancy had superior recovery rates with anterior surgery but equivalentrates with 50%involvementPatients with 5of cervical lordosis also had significantly worse outcomes from laminoplasty,and 50%lost lordosis

32、versus none in the fusion group.Half of the laminoplasty patients experienced OPLL progression versusonly one after anterior surgeryHowever,surgical complications heavily favored laminoplasty,with a 23%complication rate and a 14%reoperation rate in the anterior group and none in the laminoplasty pat

33、ientsOnly one study to date has examined the results of laminectomy and fusion for OPLL.Chen et al reported a mean recovery rate of 62%at 5 years among 83 patients who underwent instrumented laminectomy and fusion from C2 or C3 to C7.Patients with a good outcome had significantly more postoperative

34、lordosis(16.1 versus10.4).No other factors,including occupying ratio,were significant between groups.The reoperation rate was 4%,all the result of epidural hematoma formation.Whether posterior fusion had an effect on disease progression was not evaluated,although the authors noted no longterm declin

35、e in neurologic recovery,as is commonly seen in laminoplasty patients.The most common complication of posterior surgery is low cervical nerve root palsy,which occurs in 4%to 12%of patients.Injury may occur from direct trauma or from traction neurapraxia as the cord migrates posteriorlyComplications

36、specific to laminoplasty include closure of the laminoplasty and fracture of the laminar hinge,whereas laminectomy and fusion may be complicated by hardware failure,pseudarthrosis,or a post-laminectomy membraneBoth procedures can be complicated by chronic pain,loss of lordosis,epidural hematoma,and

37、progression of diseaseCombined Anterior andPosterior DecompressionWhen the disease involves more than three levels,however,the addition of a posterior decompression allows the remainder of the cervical spine to be addressed while avoiding a multilevel anterior dissection Posterior instrumentation may also be used to increase the stability of an anterior construct and promote fusion Finally,late posterior surgery may also be preferable to revision anterior surgery in the event of disease progression or pseudarthrosis