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1、医学免疫学电子资料 http:/www.cc98.org/dispbbs.asp?boardID=241 the carrier may be one which also does not elicit an immune response by itself.Complementarity determining region (CDR)A complementarity determining region (CDR) is a short amino acid sequence found in the variable domains of antigen receptor (e.g

2、. immunoglobulin and T cell receptor) proteins that complements an antigen and therefore provides the receptor with its specificity for that particular antigen.ComplementThe complement system is a biochemical cascade that helps clear pathogens from an organism. It is part of the larger immune system

3、 that is not adaptable and does not change over the course of an individuals lifetime; as such it belongs to the innate immune system. However, it can be recruited and brought into action by the adaptive immune system.MHCThe major histocompatibility complex (MHC) is a large genomic region or gene fa

4、mily found in most vertebrates. It is the most gene-dense region of the mammalian genome and plays an important role in the immune system, autoimmunity, and reproductive success. Leukocyte differentiation antigenThe cell surface markers which express or disappear on the different cells in the differ

5、ent stages of differentitation and activation.APCAn antigen-presenting cell (APC) or accessory cell is a cell that displays foreign antigen complexed with MHC on its surface. T-cells may recognize this complex using their T-cell receptor (TCR).Somatic hypermutationSomatic hypermutation (or SHM) is a

6、 mechanism inside cells that is part of the way the immune system adapts to the new foreign elements which confront it (for example, microbes). Negative selectionThe death of autoimmune lymphocytes shortly after they develop. Also known as clonal deletion. AnergyAnergy is a term in immunobiology tha

7、t describes a lack of reaction by the bodys defense mechanisms to foreign substances, and consists of a direct induction of peripheral lymphocyte tolerance. Regulatory T cellRegulatory T cells (sometimes known as suppressor T cells) are a specialized subpopulation of T cells that act to suppress activation of the immune system and thereby maintain immune system homeostasis and tolerance to self-antigens. AICDactivation-induced cell death (AICD) recognition and deletion of T lymphocytes that have been induced to proliferate by receptor-mediated activation, preventing their overgrowth.