Cypher支架.ppt

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1、Illustration by Dimitry Schidlovsky;Cell Cycle in Mammalian CellsBlood Vessel MorphologyCross-section of a Muscular ArterylumenIn-Stent Restenosis:a Problem ofExcessive Neointimal HyperplasiaDrug Release Dependent Upon:Concentration of drug Solubility of drug Molecular weight of drug Surface area of

2、 coating Presence of diffusion barriersPolymeric Stent Coating Matrixstentpolymer coatingwith drugCypher-the Sirolimus-Eluting Bx Velocity StentSlow-Release FormulationSlow-Release Formulation Topcoat Topcoat StentStentBasecoat Basecoat=polymer blend+Basecoat=polymer blend+sirolimussirolimus +Topcoa

3、t=diffusion barrier Topcoat=diffusion barrier SirolimusSirolimus is released in a controlled manner from a is released in a controlled manner from apolymer matrix bound to thepolymer matrix bound to the stent stentVascular Safety and Compatibility in a Chronic(6 month)Minipig ModelControlSirolimusSt

4、entStentStentStentLesionLesion6-Month QCA-RotterdamSao Paulo-1 year follow-upPREPREPOSTPOST4 m4 m1 y1 yCYPHER Sirolimus-Eluting StentSuperior scaffolding and nestingCoverage,flexibility,and strengthA potent and safe immunosuppressantSIROLIMUS Closed-cell design provides outstanding coverage of vessel more uniform distribution of drug therapy