Genetically modified food safety issues 生物技术转基因食品安全英文论文.doc

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1、Genetically modified food safety issuesAbstractAs we all know,modern biotechnology has brought human numerous benefits:Through the application of biotechnology, a broad and significant increase of food production can be happily seen at global agricultural production. But when we enjoy the enormous b

2、enefits of the GM food,a new but alarming problem also came that if these food is safe enough for people?if something seriously happened,what can we do?Maybe you can find some answer in this thesis.Key Words: modern biotechnology GM food safetyContentsabstract in English1chapter 1 intruduction.3chap

3、ter 2 Status of genetically modified foods4Chapter 3 GM food safety issues5Chapter 4 Conclusion10Reference11Chapter 1 IntroductionWhat is biotechnology?Maybe not too mang people know its definition accurately.Biotechnology is a technology which can reform and make the use of the natural lives on the

4、 ingredient of them by taking advantage of the research finds in life sciences which can greatly follow the will of people.In its purest form,the term biotechnology refers to the use of living organisms or their products to modify human health and the human environment. Biotechnology in one form or

5、another has flourished since prehistoric times. When the first human beings realized that they could plant their own crops and breed their own animals, they learned to use biotechnology. The discovery that fruit juices fermented into wine, or that milk could be converted into cheese or yogurt, or th

6、at beer could be made by fermenting solutions of malt and hops began the study of biotechnology. When the first bakers found that they could make a soft, spongy bread rather than a firm, thin cracker, they were acting as fledgling biotechnologists. The first animal breeders, realizing that different

7、 physical traits could be either magnified or lost by mating appropriate pairs of animals, engaged in the manipulations of biotechnology. Chapter 2 Status of genetically modified foodsAs we all know,modern biotechnology has brought human numerous benifits:Through the application of biotechnology, a

8、broad and significant increase of food production can be happily seen at global agricultural production.Since 1983 when the first time human got transgenic tobacco, potato by using recombinant DNA technology,the plant genetic engineering technology in the world has achieved rapid development of tran

9、sgenic plants for research and development,which has made a series of remarkable progress and has Successfully nurtured a number of crops with disease-resistance,insecticide resistance and even an incredible high-yield.with the help of them,we can feed another more than millions of people,According

10、to statistics,up to now ,no less than 1.6 billion people have benefits from biotechnology.in the area,our mother country China has made tremendous contributions to the worlds biotechnology.what must be mentioned is BT cotton and hybrid rice of Yuan Longping. Commercialize genetically modified crops

11、dates from the year of 1996,including Soybeans, cotton, cereals and oilseed rape.GM crops now occupy 10% of global arable land. In 2010,81% of worldwide soybean, 64% cotton, 29% and 23% of the grain is genetically modified oilseed rape.Totally,29 countries grow GM products all over the world.the top

12、 three country with the largest area of cultivation is United States, Brazil and Argentina.The problem About the safety of GM products has been controversial.Genetically modified food will bring human and animal allergens and toxins of unknown.Chapter 3 GM food safety issues International consensus

13、has been reached on the principles regarding evaluation of the food safety of genetically modified plants. The concept of substantial equivalence has been developed as part of a safety evaluation framework, based on the idea that existing foods can serve as a basis for comparing the properties of ge

14、netically modified foods with the appropriate counterpart. Application of the concept is not a safety assessment per se, but helps to identify similarities and differences between the existing food and the new product, which are then subject to further toxicological investigation. Substantial equiva

15、lence is a starting point in the safety evaluation, rather than an endpoint of the assessment. Consensus on practical application of the principle should be further elaborated. Experiences with the safety testing of newly inserted proteins and of whole genetically modified foods are reviewed, and li

16、mitations of current test methodologies are discussed. The development and validation of new profiling methods such as DNA microarray technology, proteomics, and metabolomics for the identification and characterization of unintended effects, which may occur as a result of the genetic modification, i

17、s recommended. The assessment of the allergenicity of newly inserted proteins and of marker genes is discussed. An issue that will gain importance in the near future is that of post-marketing surveillance of the foods derived from genetically modified crops. It is concluded, among others that, that

18、application of the principle of substantial equivalence has proven adequate, and that no alternative adequate safety assessment strategies are available.At an early stage in the introduction of recombinant-DNA technology in modern plant breeding and biotechnological food production systems, efforts

19、began to define internationally harmonized evaluation strategies for the safety of foods derived from genetically modified organisms (GMOs). Two years after the first successful transformation experiment in plants (tobacco) in 1988, the International Food Biotechnology Council (IFBC) published the f

20、irst report on the issue of safety assessment of these new varieties (IFBC, 1990). The comparative approach described in this report has laid the basis for later safety evaluation strategies. Other organizations, such as the Organisation for Economic Cooperation and Development (OECD), the Food and

21、Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) and the International Life Sciences Institute (ILSI) have developed further guidelines for safety assessment which have obtained broad international consensus among experts on food safety evaluation.At 1993.

22、 the OECD formulated the concept of substantial equivalence as a guiding tool for the assessment of genetically modified foods, which has been further elaborated in the following years (OECD, 1993; OECD, 1996; OECD, 1998; Figure 1). The concept of substantial equivalence is part of a safety evaluati

23、on framework based on the idea that existing foods can serve as a basis for comparing the properties of a genetically modified food with the appropriate counterpart. The existing food supply is considered to be safe, as experienced by a long history of use, although it is recognized that foods may c

24、ontain many anti-nutrients and toxicants which, at certain levels of consumption, may induce deleterious effects in humans and animals. Application of the concept is not a safety assessment per se, but helps to identify similarities and potential differences between the existing food and the new pro

25、duct, which is then subject to further toxicological investigation. Three scenarios are envisioned in which the genetically modified plant or food would be (i) substantially equivalent; (ii) substantially equivalent except for the inserted trait; or (iii) not equivalent at all. A compositional analy

26、sis of key components, including key nutrients and natural toxicants, is the basis of assessment of substantial equivalence, in addition to phenotypic and agronomic characteristics of the genetically modified plant.In the first scenario, no further specific testing is required as the product has bee

27、n characterized as substantially equivalent to a traditional counterpart whose consumption is considered to be safe, for example, starch from potato. In the second scenario, substantial equivalence would apply except for the inserted trait, and so the focus of the safety testing is on this trait, fo

28、r example, an insecticidal protein of genetically modified tomato. Safety tests include specific toxicity testing according to the nature and function of the newly expressed protein; potential occurence of unintended effects; potential for gene transfer from genetically modified foods to human/anima

29、l gut flora; the potential allergenicity of the newly inserted traits; and the role of the new food in the diet . In the third scenario, the novel crop or food would be not substantially equivalent with a traditional counterpart, and a case-by-case assessment of the new food must be carried out acco

30、rding to the characteristics of the new product.FAO（short for Food and Agriculture Organization） and WHO(World Health Organization) have been organizing workshops and consultations on the safety of GMOs since 1990. At the Joint FAO/WHO Consultation in 1996 (FAO/WHO, 1996) it was recommended that the

31、 safety evaluation should be based on the concept of substantial equivalence, which is a dynamic, analytical exercise in the assessment of the safety of a new food relative to an existing food. The following parameters should be considered to determine the substantial equivalence of a genetically mo

32、dified plant: molecular characterization; phenotypic characteristics; key nutrients; toxicants; and allergens.The distinction between three levels of substantial equivalence (complete, partial, non-) of the novel food to its counterpart, and the subsequent decisions for further testing based upon su

33、bstantial equivalence, are similar to those defined by OECD (1996).The Codex Alimentarius Commission of FAO/WHO is committed to the international harmonization of food standards. Food standards developed by Codex Alimentarius should be adopted by the participating national governments. The Codex ad

34、hoc Intergovern mental Task Force on Foods Derived from Biotechnology has the task to develop standards, guidelines and other recommendations for genetically modified foods. During its first session in Chiba (Japan) in March 2000 definitions were agreed concerning the risk assessment and risk analys

35、is of genetically modified foods. Risk assessment covers issues such as food safety, substantial equivalence and long-term health effects, while risk analysis may include decision-making and post-market monitoring.An Expert Consultation held in Geneva, Switzerland in May/June 2000 evaluated experien

36、ces gathered since the 1996 Consultation. Topics considered included substantial equivalence, unintended effects of genetic modification, food safety, nutritional effects, antibiotic resistance marker genes, and allergenicity. The Consultation endorsed the concept of substantial equivalence as a pra

37、gmatic approach for the safety assessment of genetically modified foods, and concluded that at present no suitable alternative strategies are available. Application of the concept is a starting point for safety assessment, rather than an end-point. It identifies similarities and possible differences

38、 between the genetically modified food and its appropriate counterpart, which should then be assessed further.The issue of the potential occurrence of unintended effects due to the genetic modification process, such as the loss of existing traits or the acquisition of new ones, was examined. The occ

39、urrence of unintended effects is not unique for the application of recDNA techniques, but also occurs frequently in conventional breeding. Present approaches to detecting such effects focus on chemical analysis of known nutrients and toxicants (targeted approach). In order to increase the possibilit

40、y of detecting unintended effects, profiling/fingerprinting methods are considered useful alternatives (non-targeted approach). This is of particular interest for plants with extensive modifications of the genome (second generation of genetically modified foods) where chances of the occurrence of un

41、intended effects may increase.Animal studies are deemed necessary to obtain information on the characteristics of newly expressed proteins, analogous to the conventional toxicity testing of food additives. Testing of whole foods may be considered if relevant changes in composition may have taken pla

42、ce in addition to the expected ones; however, such studies should be considered on a case-by-case basis, taking the limitations of this type of study into account. The minimum requirement to demonstrate the safety of long-term consumption of a food is a subchronic 90-day study. Longer-term studies m

43、ay be needed if the results of a 90-day study indicate adverse effects such as proliferative changes in tissues.The Expert Consultation noted that, in general, very little is known about the potential long-term effects of any foods, and that identification of such effects may be very difficult, if n

44、ot impossible, due to the many confounding factors and the great genetic variability in food-related effects among the population. Thus the identification of long-term effects specifically attributable to genetically modified foods is highly unlikely. Epidemiological studies are not likely to identi

45、fy such effects given the high background of undesirable effects of conventional foods. The Consultation was of the opinion that pre-market safety assessment already gives an assurance that genetically modified foods are as safe as their conventional counterparts. Experimental studies, such as rando

46、mized controlled human trials, if properly performed, might provide additional evidence for human safety in the medium to long term.英语谚语警句100句精选Proverbs are the daughters of daily experience.谚语是日常经验的结晶。1. Look before you leap./Second thoughts are best. 三思而后行。/再想而后行。2. Great minds think alike; (heroe

47、s have similar views.) 英雄所见略同。 3. We shall never have friends if we expect to find them without fault.欲求完美无缺的朋友必然成为孤家寡人。4. What you sow, you must mow. 种瓜得瓜，种豆得豆。5. A beggar can never be bankrupt.天无绝人之路。6.A friend in need is a friend indeed.患难见真情。7. No news is good news. 没有消息就是好消息。8. No cross, no cro

48、wn. 不经历风雨,怎么见彩虹。9. The more haste, the less speed. /Haste makes waste.欲速则不达。10. Victory belongs to the most persevering. 坚持就是胜利！11. A young idler, an old beggar. 少壮不努力，老大徒伤悲。12. Put ones foot in ones mouth. 说话不得体。13. It is no use crying over spilt milk.覆水难收/悔恨已晚/木已成舟,回天乏力。14. Content is better than

49、riches. 知足常乐。15. No gains without pains. 没有辛苦就没有收获。16. The more a man knows, the more he is inclined to be modest. 大智若愚。17. All roads lead to Rome .条条大路通罗马。18. A snow year, a rich year. 瑞雪兆丰年。19. Never say die! 永不言败！20. The best mirror is a friends eye. 朋友的眼睛是最好的镜子。 21. Faith will move mountain. 精诚所至，金石为开。 22. A life without a friend is a life without a sun. 人生没有朋友，犹如生活没有了太阳。 23. Great wits have short memories.贵人多忘事。 24. Do well and have well. 善有善报。