Introduction.ppt

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1、WelcometoattendProf.RongwuYangslecture!,Welcometoenterthemysteriousbiochemicalworld!,BiochemistryBiochemistry.mp3,BiochemistryBiochemistryIwishthatIwerewiserIfeelIminwayovermyheadIneedanewadvisorMycoursesreallyshouldntbSuchmetabolicmiseryBiochemistryBiochemistryIwishthatIwerewiserBiochemistryBiochem

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3、ochemistryBiochemistryIwishthatIwerewiser,Biochemistry(cont.),SomeRulesorSuggestions,TurnoffyourcellphoneorswitchitintosilentmodewheninclassDonttakenotestooseriously,JustfocusonlisteningandunderstandingEitheryoucomehereontimeoryouwontYoucansleepinclass,butdontsnore!Dontaskmeformercywhenyougetpoorgra

4、desinthiscourse,Please.turnallcellphonesoff,Orswitchthemintosilentmode,ViolationsandPenaltiesZero-tolerancePolicyEachtime:Lossof5pointsorbuyeveryoneintheclassroomonecupofcoffeeoroneicecreamDuringExam:Lossof10points,Wheninclass,GradingPolicy,ClassParticipation:5%TermpaperorTranslation:5%Quiz:10%Mid-t

5、ermExam:30%FinalExam:50%Extracredit(10points):presentation,Generaltipsonhowtosucceed,Justdoasaproverbsays:Ihear,andIforget,Isee,andIremember,Ido,andIunderstand.,Morespecifictipsforsuccess,Readthebookasmuchasyoucan.Printouttheslidesandbringthemtolecture.Takeadditionalnotesontheslidesinlecture.Donttak

6、enotestooseriously,Justfocusonlisteningandunderstanding.Donthesitatetoaskquestions.Dontwaituntilthedaybeforetheexamtocram.,Iurgeyouandencourageyou:,BesuretocontactmebysendingyourfeedbacktoaskmenowwheneveryougetanytroublestudyingBiochemistry,Textbooks,生物化学原理第二版（高等教育出版社杨荣武主编）PrinciplesofBiochemistry.生

7、物化学学习指南与习题解析（高等教育出版社杨荣武主编）StudyguideandProblemsolvingforBiochemistry.SomeEnglishtextbooksarealsorecommended:(1)LehningerPrinciplesofBiochemistry(2)VoetFundamentalsofBiochemistry,Somerecommendedwebsites,Moleculeoftheyear,1989PCRandDNApolymerase1990themanufactureofsyntheticdiamonds1991buckminsterfulle

8、rene1992nitricoxide1993p531994DNArepairenzyme1995BoseEinsteincondensate,Breakthroughoftheyear,1996understandingHIV1997Dollythesheep,thefirstmammaltobeclonedfromadultcells1998theacceleratinguniverse,darkmatter1999capturingthepromiseofyouthwithstemcells2000Fullgenomesequencing2001nanocircuitsormolecul

9、arcircuit2002smallRNAs2003darkenergy2004SpiritroverlandedonMars2005evolutioninaction2006proofofthePoincarconjecture2007Humangeneticvariation2008Cellularreprogramming2009Ardipithecusramidus2010Thefirstquantummachine2011theHPTN052clinicaltrial,aninternationalHIVpreventiontrial2012HiggsBoson2013CancerI

10、mmunotherapy,TheToptwoScientificAchievementsof2010,CraigVenter&SynthiaFelisaWolfe-Simon&GFAJ-1,WhoisCraigVenter？,CreationofSynthia,WhoisFelisaWolfe-Simon？,MonoLake,GFAJ-1,2013NobelPrizeinPhysiologyorMedicine,TheprizewasawardedjointlytoJamesE.Rothman,RandyW.SchekmanandThomasC.Sdhoffortheirdiscoveries

11、ofmachineryregulatingvesicletraffic,amajortransportsysteminourcells,2012NobelPrizeinPhysiologyorMedicine,Theprizewasawardedjointlyto:JohnB.GurdonAndShinyaYamanakaforthediscoverythatmaturecellscanbereprogrammedtobecomepluripotent,2012NobelPrizeinChemistry,Theprizewasawardedjointlyto:RobertJ.Lefkowitz

12、andBrianK.KobilkaforstudiesofG-protein-coupledreceptors,IntroductiontoBiochemistry,WhatisBiochemistryabout?Bio+Chemistry=BiochemistryTheGoalsofBiochemistryDescribestructure,organization,functionofcellsinmolecularterms(1)Structuralbiochemistry(2)Metabolicbiochemistry(3)MolecularbiologyTheRootsofBioch

13、emistryTheUsesofBiochemistry,SomeMilestonesintheDevelopmentofBiochemistry,Wohlerssynthesisofurea：“ImusttellyouthatIcanprepareureawithoutrequiringakidneyorananimal”BuchnersfermentationofsugarfromyeastextractsSumnerscrystallizationofureaseFlemmingsdiscoveryofchromosomesMendelscharacterizationofgenesMi

14、eschersisolationofnucleicacidsWatsonandCricksstructureofDNAGenomicsandproteomics,TheUsesofBiochemistry,Agriculture-GMfoodDisease-ALSandEVDMedicine-GeneTherapyNutrition-Anti-obesityClinicalChemistry-BiochemicalDiagnosisvita2005.pdf；tdy_curry_fibrosis_030617.asfPharmacology-AZTandViagraToxicology-Rici

15、n,ALSandALSIceBucketChallenge,Amyotrophiclateralsclerosis(ALS):肌肉萎缩性侧索硬化症Todate,anumberofgeneticmutationshavebeenassociatedwithvarioustypesofALSAdefectonchromosome21,whichcodesforsuperoxidedismutase,isassociatedwithapproximately20%offamilialcasesofALS,orabout2%ofALScasesoverall,ForALSfamilies,coping

16、istherealchallenge.pdf,Ebolavirusdisease(EVD)orEbolahemorrhagicfever(EHF),Ebolavirionscontainlinearnonsegmented,single-strand,non-infectiousRNAgenomesofnegativepolarity,Listencarefullyandtellmewhatitisabout,Keywords:cysticfibrosis(囊性纤维变性)glutathione(谷胱甘肽)Mucus(粘液),Homework,Readthearticle“MeridianMagazine.pdf”andgetreadyforansweringanyquestionsfromme.Watchthevideoclip“theinnerlifeofthecell”(withoutcaption)andaskyourselfhowmuchyouknow.theinnerlifeofthecellharvard.swf,