09级二系英语回忆.docx

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1、本资料来自 cc98 http:/www.cc98.org/dispbbs.asp?boardID=2413*8第一篇貌似就是以下这篇文献Myocardial CXCR4 Expression Is Required for Mesenchymal Stem Cell Mediated Repair Following Acute Myocardial Infarction.BACKGROUND: Over-expression of SDF-1 in injured tissue leads to improved end-organ function. In this study we q

2、uantify the local trophic effects of mesenchymal stem cell (MSC) SDF-1 release on the effects of MSC engraftment in the myocardium after acute myocardial infarction (AMI). METHODS AND RESULTS: Conditional cardiac myocyte CXCR4 (CM-CXCR4) null mice were generated using tamoxifen inducible cardiac spe

3、cific cre by crossing CXCR4 floxed with MCM-cre mouse. Studies were performed in littermates with (CM-CXCR4 null) or without (control) tamoxifen injection 3 weeks before AMI. One day after AMI mice received 100,000 MSC or saline via tail vein. We show MHC-MerCreMer and the MLC-2v promoters are activ

4、e in cardiac progenitor cells (CPC). MSC engraftment in WT mice decreased TUNEL+ CM (-44%, p0.01), increased CPC recruitment (100.9%, p0.01) and increased cardiac myosin positive area (39%, p0.05) at 4, 7 and 21 d after AMI, respectively. MSC in WT resulted in 107.4% (p0.05) increase in ejection fra

5、ction compared to 25.9% (p=NS) increase in CM-CXCR4 null mice. These differences occurred despite equivalent increases (16%) in vascular density in response to MSC infusion in WT and CM-CXCR4 null. CONCLUSIONS: These data demonstrate that the local trophic effects of MSC require CPC- and CM-CXCR4 ex

6、pression and are mediated by MSC SDF-1 secretion. Our results further demonstrate and quantify for the first time a specific paracrine mechanism of MSC engraftment. In the absence of CM-CXCR4 expression there is a significant loss of functional benefit in MSC mediated repair despite equal increases in vascular density.五个选择一个问答。问答问的是为什么要 tamoxifen injection当时做的蛋疼死了。第二篇比较简单，一个选择文中可以找，一个名词翻译 recanalization5.简答；8 分*2what have you learned after the class of molecular imaging？第二个是认为一个合格的 physician 要具有哪些特质